![Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling](https://www.science.org/cms/10.1126/scisignal.aai8441/asset/236282b7-67c8-485b-87f5-2c5e8c53b95c/assets/graphic/9_ra117_f1.jpeg)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling
![A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0031942217300420-fx1.jpg)
A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect
![Effects of the Kappa Agonist U69,593 on Naltrexone's Discriminative Stimulus Effect in Subjects Given Chronic, Intermittent Sucrose Access Effects of the Kappa Agonist U69,593 on Naltrexone's Discriminative Stimulus Effect in Subjects Given Chronic, Intermittent Sucrose Access](https://minds.wisconsin.edu/bitstream/handle/1793/81231/StuttSpr19.pdf.jpg?sequence=4&isAllowed=y)
Effects of the Kappa Agonist U69,593 on Naltrexone's Discriminative Stimulus Effect in Subjects Given Chronic, Intermittent Sucrose Access
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects | Biological and Medicinal Chemistry | ChemRxiv | Cambridge Open Engage 6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects | Biological and Medicinal Chemistry | ChemRxiv | Cambridge Open Engage](https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c7562f702a9b08b618c87e/largeThumb/6-5-fused-ring-c2-salvinorin-ester-dual-kappa-and-mu-opioid-receptor-agonists-as-analgesics-devoid-of-anxiogenic-effects.jpg)
6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects | Biological and Medicinal Chemistry | ChemRxiv | Cambridge Open Engage
![Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/067b22436f475a7fe6209c314a4fa942dd154a0f/3-TableII-1.png)
Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g002.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience](https://www.jneurosci.org/content/jneuro/34/12/4239/F4.large.jpg)
Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting” | Journal of Neuroscience
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence
![A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41386-017-0006-4/MediaObjects/41386_2017_6_Fig1_HTML.jpg)
A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology
![Buy Biochemical Events Induced by the Specific Kappa-Opioid Receptor Agonist, U50488h Book Online at Low Prices in India | Biochemical Events Induced by the Specific Kappa-Opioid Receptor Agonist, U50488h Reviews & Ratings - Buy Biochemical Events Induced by the Specific Kappa-Opioid Receptor Agonist, U50488h Book Online at Low Prices in India | Biochemical Events Induced by the Specific Kappa-Opioid Receptor Agonist, U50488h Reviews & Ratings -](https://m.media-amazon.com/images/I/41c8YwzSIDL.jpg)
Buy Biochemical Events Induced by the Specific Kappa-Opioid Receptor Agonist, U50488h Book Online at Low Prices in India | Biochemical Events Induced by the Specific Kappa-Opioid Receptor Agonist, U50488h Reviews & Ratings -
![Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41598-021-88118-6/MediaObjects/41598_2021_88118_Fig4_HTML.png)
Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports
![Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys | Journal of Pharmacology and Experimental Therapeutics Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys | Journal of Pharmacology and Experimental Therapeutics](https://jpet.aspetjournals.org/content/jpet/286/2/812/F1.large.jpg)
Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys | Journal of Pharmacology and Experimental Therapeutics
Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold | ACS Chemical Neuroscience
![Nephrology Journal Club on Twitter: "Difelikefalin (CR845) (KORSUVA) is a peripherally restricted, selective kappa opioid receptor agonist that exerts antipruritic effects by means of activation of kappa opioid receptors on peripheral neurons Nephrology Journal Club on Twitter: "Difelikefalin (CR845) (KORSUVA) is a peripherally restricted, selective kappa opioid receptor agonist that exerts antipruritic effects by means of activation of kappa opioid receptors on peripheral neurons](https://pbs.twimg.com/media/EJQpY99U4AY2hKN.jpg)